I have tried many flavors of Linux (I presume you mean desktops - I've run GNOME, KDE, Xfce, and a bunch of others), and I run Fedora (dev) and Ubuntu (HTPC) boxes at home. I've tinkered with switching fulltime to Linux desktops a number of times, and they're great 99% solutions, but the big showstoppers for me have been DRM'd video (Netflix, Amazon) and Steam (I'm a gamer, and 95% of my library doesn't run on Linux). With my setup, literally everything I care about runs without any real effort, and I don't sacrifice any dev power.
The really nice thing about my setup is that because all I need is an SSH client, I can work from my Chromebook, Macbook, or even my phone if I have to, and I have full access to my whole dev environment from anywhere. The biggest thing I've lost is the ability to attach to processes directly to debug them, but I just end up using terminal-level debugging or remote debugging facilities when they're available, and it works fine.
Netflix now works under Chrome (not Chromium) as of...October? But Amazon has broken as of a few months before that - they switched the DRM they use and the old solutions are no longer valid. As far as I know, there is no workable solution for Amazon video on Linux anymore.
DRM-protected video in general is a giant pain in the ass that you don't really notice on the "blessed" platforms.
